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Silvestrol aglycone

CAS No. 960365-65-5

Silvestrol aglycone ( —— )

Catalog No. M16856 CAS No. 960365-65-5

Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Silvestrol aglycone
  • Note
    Research use only, not for human use.
  • Brief Description
    Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway.
  • Description
    Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway; effectively targets the cyclin/CDK/Rb pathway, and additionally induces cytotoxicity via intrinsic apoptosis, exhibits low nanomolar potency both in MCL cell lines and primary MCL tumor cells; demonstrates B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    960365-65-5
  • Formula Weight
    478.49
  • Molecular Formula
    C27H26O8
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    COC1=CC=C(C=C1)C23C(C(C(C2(C4=C(O3)C=C(C=C4OC)O)O)O)C(=O)OC)C5=CC=CC=C5
  • Chemical Name
    1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 2,3,3a,8b-tetrahydro-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lucas DM, et al. Blood. 2009 May 7;113(19):4656-66.
2. Kim S, et al. Anticancer Res. 2007 Jul-Aug;27(4B):2175-83.
3. Hwang BY, et al. J Org Chem. 2004 May 14;69(10):3350-8.
4. Alinari L, et al. Clin Cancer Res. 2012 Sep 1;18(17):4600-11.
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